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Description
BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion
Any consideration of combination pharmacotherapy should involve shared decision-making, thorough discussion of risks and benefits, and close clinical follow-up
nevertheless, they do not comprehensively reflect the complex etiology and chronic development observed in humans
This neuroinflammatory cascade also heavily impacts the autonomic nervous system, contributing to the development of dysautonomia and Postural Orthostatic Tachycardia Syndrome (POTS)
