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For the purpose of this review, we define dysbiosis as a maladaptive imbalance in the microbial community structure, characterized by a loss of diversity, a reduction in beneficial commensals, and an expansion of pathobiontsthat disrupts hostmicrobe homeostasis and contributes to disease pathology [38]

Apart from the respiratory epithelial cells, ACE2 is also significantly expressed in the endothelium of the heart, kidney, intestine, testis, and ovary, leading to systemic transmission to other organs [6]

The multifunctional roles of HDAC6 extend far beyond its involvement in neurodegenerative diseases, cardiovascular disorders and metabolic conditions, as its influence is significantly noted across various types of cancers