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Calorie restriction or exercise also increases tissue NAD+ content thereby activates SIRT1, which then activates PGC-1 through deacetylation [178]

10.1016/j.neuron.2013.03.024 Neuron 38 MllerM.Du PreezJ

10.1016/S0065-2318(00)55005-7 70 WandersR
Vitamin C was well tolerated
