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10.1155/2018/5234943 85 McDonaldB

Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, characterized by demyelination and neurodegeneration

A phase II study of autologous mesenchymal stromal cells and c-kit positive cardiac cells, alone or in combination, in patients with ischaemic heart failure: the CCTRN CONCERTHF trial

The main in vitro tests commonly used are: the tolerance to acidity and gastric enzymes, the tolerance to bile, and intestinal enzymes, the adhesion to intestinal cells and the persistence in the digestive tract, and the lack of pathogenic behavior ( In vitro tests are informative but complementary in vivo approaches is mandatory for a better characterization of probiotics mechanism of action but also safety aspects