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Since there is significant pruning and differentiation of neurons during adolescence 44 , EZH2 dysregulation and an increase in repressive H3K27me3 marks at the BDNF and ARC regulatory regions by alcohol drinking during this critical period could contribute to an increased risk of AUDs and higher overall alcohol consumption later in life (Fig

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A better understanding of the microbiome-immune system interactions will help us develop more targeted, specific antitumor medications in the future