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Discussion With our approach combining epidemiological studies, explorative cellular experiments and murine interventions, we demonstrate that kidney function is the main modifiable factor consistently regulating fasting serum TMAO concentrations and that TMAO adversely impacts on eGFR, at least partially, by increasing kidney scarring synergistically with existing pathophysiology elevating kidney tissue TGF-1 signaling

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: L-Carnitine Improves Skeletal Muscle Fat Oxidation in Primary Carnitine Deficiency Karen Lindhardt Madsen et al
