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Dietary supplements, including green tea extract (particularly when standardized to have a high catechin concentration) and kava, black cohosh, high-dose curcumin, and some Chinese herbal preparations, are implicated in hepatocellular injury, cholestasis, or fulminant hepatic failure in both single case reports and small clinical series

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This raises the question of whether mitochondrial dysfunction could be a factor that causes the disease to progress

This meta-analysis included 17 clinical studies in total (enrolling 26,167 subjects) and had a median of 4.3 1.5 years of mean follow-up