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9a), Arbutin, which has a smaller molecular weight, tends to chelate with copper ions, interacting with H84, V282, and F263, with the hydroxyphenyl group directed towards the metal site

Factorial experimental designs with single-compound and combined-compound treatment arms, alongside vehicle controls, allow researchers to statistically distinguish independent compound effects from any combination-specific outcomes on NAD+ pathway and mitochondrial redox endpoints, a standard approach in multi-compound cellular metabolism research.

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