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doi: 10.1161/CIRCULATIONAHA.105.594077 175
2016;34(15-suppl):9067
[169] [170] [171] Consistent with Coleman's and Leibel's hypothesis, several subsequent studies from Leibel's and Friedman's labs and other groups confirmed that the ob gene encoded a novel hormone that circulated in blood and that could suppress food intake and body weight in ob and wild type mice, but not in db mice

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