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In the dithiol mechanism, the transiently formed Grx-GSH-mixed disulfide is attacked by the second active-site cysteine of Grx leading to the formation of an intramolecular disulfide bond (Fig

however, its concentration at physiological pH is very low compared to the concentration of superoxide (at pH = 7, ratio O 2 : HOO = 100: 1)

E-SLNs were made with hot micro-emulsion and were optimized by central composite model
