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F., et al., The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson's Disease, Aging Dis 9, no

115,116 D-aspartate (D-Asp) has been shown to influence the signaling of NMDARs by acting as an agonist to bind to the agonist site of NMDARs and activate this glutamate receptor

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Previously, a study based on proteomic analysis had revealed marked transcriptional repression of other Nrf2-induced antioxidant proteins including CK2, ERK1/2, PKC, GPx, Mgst1, peroxiredoxin 3 (Prdx3), in both preclinical models and in human spinal MNs from ALS patients [253]