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Neuroprotective molecular mechanisms of (-)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties
In a first part, I discuss biological issues related to the persistence of microbial antigens, dysregulated immune responses, reactivation of latent viruses, different potential self-sustained inflammatory loops, mitochondrial dysfunction, metabolic disorders in the tryptophan- kynurenin pathway (TKP) with impact on serotonin, and consequences of a dysfunctional bidirectional microbiota-gut-brain axis

Girish BN, Rajesh G, Vaidyanathan K
TEM showed that LPS-induced inflammatory colon epithelial cells exhibited microscopic morphological characteristics of ferroptosis, such as mitochondrial condensation and mitochondrial cristae reduction, while HIF-1 overexpression impaired the mitochondrial damage in the colonic epithelial cells (Fig