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The consequences of Cd hitting mitochondria include oxidative stress, the production of ROS, the start of apoptosis, the mutation of MTs-DNA, the modification of gene expression, the inhibition of respiratory chain complexes, the reduction of ATP synthesis, and the modification of endo-mitochondrial conductivity

The peptide crosses the blood-brain barrier to some extent, which is important for a compound intended to affect central nervous system function

[DOI] [PMC free article] [PubMed] [Google Scholar] 78.McMullen R.L

The current evidence supports safety and efficacy for acute use, but extrapolation to extended PCT protocols relies partly on mechanistic understanding rather than direct clinical trial data