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CDK4/6 inhibitors are now widely employed in breast cancer treatment and are being evaluated in various other malignancies

In addition, insulin resistance caused by mitochondrial dysfunction may lead to metabolic and cardiovascular abnormalities, thereby increasing the incidence of CVD (38, 45)

Therefore, the subsequent effects of the JAK/STAT signaling pathway may synergize with other mechanisms and are related to the properties of its upstream ligands

Nivalenol, a trichothecene mycotoxin induces apoptosis in HL60 cells and that intracellular calcium ion plays a role in the nivalenol-induced secretion of IL-8 from this cell line [178]