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Metals like lead and mercury can catalyze ROS production, while pollutants and industrial chemicals trigger oxidative stress by promoting free radical production, depleting antioxidants, and inhibiting their protective functions

The biggest challenge for the clinical use of SM in treating MSDs lies in the need for rigorous scientific validation through well-designed clinical trials

Quality of life prior to TKR surgery, and the probability of progression to TKR surgery, make smaller, although similar, contributions in comparison
