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After tobacco is set into the field, it is generally cultivated twice, manually hoed to remove remaining weeds, inspected often for insect damage, and sprayed approximately every two weeks for insects, Lennie said

The toll from tobacco alone comes to $6.8 billion, taking into account health-care costs, costs incurred from secondhand smoke and lost productivity due to smoking-related diseases and smoking on the job

Effects of a 24-hour fast on cigarette smoking in humans