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The slow-release mechanism of a nicotine patch focuses on reducing peaks and troughs in nicotine levels, which can make the quitting process more balanced and less stressful

Tobacco and nicotine delivery product use in a national sample of pregnant women

[9] on FTND and HSI relevance, there was considerable agreement between the HSI and FTND, with a kappa value of 0.7 and 96.2% specificity

WHO Report on the Global Tobacco Epidemic 2008 : The MPOWER Package (PDF)
