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Additional strategies are needed to drive down smoking prevalence, save lives and reduce ill health, as rapidly as possible

Dong and colleagues have reported in MCF7 cells (human breast adenoma line) that estrogen enhances peptidyl arginine deiminase (PAD) type 4 (see information about PADs below) expression via the estrogen receptor alpha activator protein-1 pathway [27]

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In that study, ATR-dependent Pol-mediated end joining, 53BP1-directed shieldin/CST-Pol-primase fill-in synthesis, and CtIP/MRN-dependent strand annealing produced distinct junction signatures