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[66] combined the microgram weight of the compound in the smoke of one cigarette with the known genotoxic effect per microgram to identify the most carcinogenic compounds in cigarette smoke

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With tobacco use, there's a significant risk of developing chronic lung conditions such as chronic obstructive pulmonary disease, of which bronchitis and emphysema are components, chronic cough, shortness of breath, increasingly frequent and severe asthma episodes

Despite their buccal absorption, 4 mg pouches (most commonly used), deliver similar total nicotine exposure to cigarettes, though with lower peak concentrations and slower absorption