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36 Although direct evidence from OA-specific exposure models is still limited, it is biologically reasonable to think that smoking-related oxidative stress may increase DAMP release and strengthen DAMPTLR/RAGENF-B signaling in the synovial-cartilage unit

President and CEO Andrew Clyde said the results fell slightly short of internal expectations. If theres one thing that has stood out over the past decade, its that every quarter is just a little bit different, Clyde told analysts Thursday