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Previous reports of this and other studies 13 , 14 , 17 , 21 , 22 have reviewed the associations of smoking with many specific causes of death and considered the reasons for them, leading to the conclusion that in this study the substantial differences between smokers and non-smokers in overall mortality are due chiefly to the causal effects of smoking

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[25] Efficacy studies, which are conducted using randomized controlled trials, do not transfer very well to real-world effectiveness

These also work if you smoke cigars or pipes and may work for other tobacco products as well, such as chew or snuff