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Key Toxic Chemicals in Tobacco Smoke Cigarette smoke contains over 7,000 chemicals, many of which damage ocular tissues: Formaldehyde and acetone irritate the corneal surface

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Pesticides including organochlorines (e.g., DDT) and other persistent organic pollutants are used in tobacco cultivation, especially in low- and middle-income countries

For the cohort born in the 19th century the cigarette smoker versus non-smoker relative risk when they were over 60 years of age was only 1.46 (excess mortality 46%), but for the cohort born in the 20th century it was 2.19 (excess mortality 119%)