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For former heavy smokers taking CYP1A2-metabolized drugs, dose adjustments after cessation are essential to avoid elevated drug levels and adverse drug reactions (ADRs)

Strengths and limitations The main strength of this study lies in its large sample size

The latter had significant excess mortality from all causes (HR = 1.25, CI = 1.081.46), but not from heart diseases (HR = 1.16, CI = 0.851.59), malignant neoplasms (HR = 1.17, CI = 0.831.67), and all smoking-related diseases (HR = 1.19, CI = 0.971.46)