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Licenses must be renewed annually

In addition to returning Fox Mulder (David Duchovny) and Dana Scully (Gillian Anderson), the revived Fox series brings back memorable characters like Walter Skinner and the Cigarette Smoking Man (aka Cancer Man) and introduces a handful of new guest stars

E-cigarettes often contain nicotine and other cancer-causing chemicals

An overall summary and simplification of these effects is illustrated with Figure 1
