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Tobacco stocks face regulatory uncertainty with GST 2.0 implementation from February 1, 2026 and excise hikes, declining consumption due to health awareness, ethical concerns limiting ESG investor participation, litigation risks, illicit trade competition exacerbated by sharp price increases, advertising restrictions, and potential volume decline of 6-8% as per CRISIL forecast
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12, 2432 10.1037/0278-6133.12.1.24 [DOI] [PubMed] [Google Scholar] Cannon B., Nedergaard J

Clinical treatment paradigms will need to evolve to incorporate the role of p53 loss and mutation, accounting for the differential effect on outcomes and our current inability to directly target p53 status in tumors