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Albeit the cEDS-specific triad, i.e., widened, atrophic scars (92% of patients and ~ 95% of probands), marked skin hyperextensibility (80% of patients and ~ 82% of probands), and gJHM (BS 5, ~ 59% of patients and ~ 66% of probands), is highly predictive for molecular confirmation of the diagnosis, this combination was observed only in ~ 49% of patients and in ~ 55% of probands