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The rationale for studying Appalachian residence in addition to rural residence is that while the Appalachian region faces similar challenges to rural areas, it is a unique geographical area of historical independence and resilience, with health disparities in Appalachia especially pronounced in part due to its well-documented social disadvantages, history of economic exploitation, and increased environmental exposure 19

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The mechanism underlying the amplification of the transcriptional regulatory cascade of jasmonic acid (JA) in response to disease was discovered in tomato through combined ChIPseq and RNAseq analyses, offering new perspectives for breeding diseaseresistant varieties (Du et al., 2017)