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Notably, the observed reductions in the odds of substance use disorders, including a 74% decrease in the odds of AUD, a 69% reduction for OUD, a 68% reduction for NUD, and a 75% reduction for CUD, among GLP-1 RA users were consistent with emerging preclinical and clinical studies showing that GLP-1 RA modulates reward pathways in the brain to reduce SUD (32)

Hypoglycemia Inform patients that the incidence of hypoglycemia is increased when JANUVIA is added to a sulfonylurea or insulin

First, GLP1 therapies promote weight loss, which can significantly improve insulin sensitivity

These Phase 3 trials enrolled thousands of participants across multiple studies, providing robust evidence for efficacy and safety
