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A study using Swedish and Danish national databases compared cancer incidence in over 20,000 GLP-1 users versus other diabetes medications and found no elevated risk for colon or rectal cancers during follow-up periods extending beyond three years

However, with stronger glucagon receptor stimulation, it would be important for further pre-clinical studies to characterise the effects of lead drug candidates, on plasma amino acids and lean mass

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Tirzepatide starts at 2.5 mg per week for four weeks before increasing to 5 mg
