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There were no statistically significant interactions by treatment and background medication subgroup for change in HbA1c or body weight except for change in HbA1c (background insulin vs insulin plus metformin) in PIONEER 8 (p=0.0408)

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There is direct evidence comparing semaglutide to sitagliptin and dulaglutide in patients inadequately controlled on one oral antidiabetic drug (OAD), and to exenatide or insulin glargine in patients with inadequate glycemic control with one or two OADs, however data are lacking for other comparators