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Exenatide (Byetta & Bydureon) - What are they and are they worth using Medically reviewed by Dr Sultan Linjawi, Endocrinologist & Diabetes Specialist January 2026 Exenatide was the first GLP-1based medication approved for the treatment of type 2 diabetes and marked a major shift in how diabetes medications work

A series of clinical and experimental studies demonstrated that GLP-1RAs have beneficial effects on DKD, independent of their glucose-lowering abilities, which are mediated by natriuresis, anti-inflammatory and anti-oxidative stress properties

When prescribed by licensed providers and prepared by reputable pharmacies, they are generally considered safe and effective

Patient Educ Couns 68:1015 Chabenne JR, DiMarchi MA, Gelfanov VM, DiMarchi RD (2010) Optimization of the native glucagon sequence for medicinal purposes