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That damage is permanent
In comparison, the pancreatic islets isolated from the GLP-1R knock-out mice secreted 2 to 4-fold less insulin after incubation with GLP-1 WT, GLP-1 QMP, or Exendin-4, similar amounts to that measured for unfused WT albumin (Fig
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The role of endogenous GLP-1 in inflammation remains unclear
