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This makes them slower to respond when the body taps fat for fuel, which is why so many of us plateau even with rigorous diets or extra workouts

Few semaglutidetreated participants (4.3%) permanently discontinued treatment for GI AEs

Furthermore, in response to stress, male germ-free mice display a hyper reactive HPA axis, thus suggesting an important role of the microbiota in HPA regulation [8]

Key Takeaways Anxiety is reported, but it is not the usual outcome Timing matters, especially after dose increases Low intake and dehydration can mimic anxiety Sleep disruption can amplify anxious feelings New severe symptoms deserve prompt clinical review Is Anxiety a Side Effect of Zepbound