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If you have any of the following conditions then you may benefit more from the combination of Wellbutrin plus Naltrexone over just Wellbutrin alone: ALL of the conditions listed above for Wellbutrin PLUS: Patients who suffer from thyroid problems ( Hypothyroidism , Hashimotos thyroiditis , Thyroid resistance , etc.) Patients with chronic inflammation or chronic pain syndromes (these often lead to weight gain through the use of narcotics) Patients with blood sugar issues, type II diabetes, or insulin resistance Patients suffering from autoimmune diseases Patients who fall on the PCOS spectrum or who have a known diagnosis of PCOS By adding a low dose of naltrexone the list of conditions and people that benefit from Wellbutrin increases dramatically