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This review article evaluates the status of presently approved anti-obesity medications like lipase inhibitors, incretin-based medicines, dual agonists, and melanocortin receptor agonists for their adverse events, alongside novel therapeutic candidates under clinical investigation

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The combination therapy of GLP-1 receptor agonists and metformin demonstrates superior safety over monotherapy, while revealing novel adverse events and demographic-specific risk patterns, thereby offering reliable evidence to inform clinical practice.

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