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This dampening effect reduces the reinforcement that would typically occur that leads to repeated use of the substance

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These organoids were treated with inflammatory stimuli (TNF, IFN, LPS), microbial structures (MDP, LPS), and an OXPHOS inhibitor (oligomycin) to assess the effects on GLP-1 secretion, EEC marker gene expression ( CHGA , TRIB3 ), and overall epithelial differentiation

Strategies that may reduce side effects include: Eating smaller meals Avoiding high-fat or heavy foods Maintaining hydration Following the prescribed titration schedule Serious but Rare Risks Serious side effects are uncommon but may include: Pancreatitis Gallbladder disease Severe dehydration Kidney complications (often related to dehydration) There is also a boxed warning regarding thyroid C-cell tumors observed in animal studies