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In the SURPASS and SURMOUNT trials, Lilly has so far compared tirzepatide to older treatments or placebo (for T2D and obesity)

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells

Here is the most important takeaway: As of late 2025, there are no FDA-approved GLP-1 medication patches (semaglutide, tirzepatide, or others) commercially available from a legitimate pharmacy

Healthline Muscle Loss & Ozempic/Wegovy: What to Know About Muscle Loss While Taking Semaglutide