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The study reviewed records of over one million patients prescribed a GLP-1 between January 2018 and December 2023

Gradual dose titration is the primary mitigation strategy and a critical component of the dosing protocol

In a randomized controlled trial, tirzepatide at doses of 10 mg and 15 mg resulted in an average weight reduction of 20% and 21%, respectively, while the 5 mg dose led to a 15% weight loss, compared to 3% with placebo
