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Susan Sweeney, Amgen's senior vice president and head of obesity, said, Weight loss is important, but finding a way for patients to manage their disease long term and maintain their weight is even more important. Finding ways to reduce fat while preserving muscle mass is another competitive advantage that next-generation obesity drugs can offer

This finding positions it as a compound of significant interest in hepatic metabolic research, a field where effective interventions have historically been limited

Metabolism : Like other peptide therapeutics, retatrutide is expected to be degraded through general proteolytic pathways rather than hepatic cytochrome P450 metabolism