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This sample size provides at least 80% power for the comparison of tirzepatide versus placebo for the change in energy intake during ad libitum test meals (primary outcome) based on a two-sample t -test at an alpha level of 0.05, given an expected treatment difference of 212 kcal and an assumed common standard deviation of 289 kcal for the change in energy intake from baseline

Does energy expenditure fluctuate with dosing schedule Some researchers theorize that the mild energy fluctuations throughout the weekly tirzepatide cycle, slightly higher metabolic rate during peak drug levels, slightly lower during the trough, could be optimized through strategic timing

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