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Anti-Inflammatory Effects: GLP-1 medications may reduce inflammation, address insulin resistance, and improve metabolic function by reducing visceral fat
Published Phase 2 trial data for retatrutide (Jastreboff et al., NEJM , 2023) demonstrated significant reductions in body weight and improvements in cardiometabolic markers
Typically 60-80% less than retail pharmaceutical pricing, making long-term treatment more financially feasible for many patients
4f) UniFrac in PCoA and in the NMDS plot (Supplementary Fig
