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doi: 10.1210/jcemcr/luac017 47 TanXPanXWuXZhengSChenYLiuDet al

The reduction in -cell mass in patients with T2DM can be attributed to -cell apoptosis triggered by multiple factors, including islet amyloid deposition, lipotoxicity, glucotoxicity, and inflammation (You et al., 2022)

Important limitations: No detailed tumor biology or treatment data No information on whether patients consistently took the medications No weight change data Possible unmeasured differences between groups despite matching Many patients had not been followed for the full 10 years, so later long-term estimates are based on fewer patients and are less precise So what does this mean

While certain competitors may engage in price or generic competition, the sustainability of such leadership will only be achieved by players who have differentiated oral delivery systems, solid trial data, robust real-world evidence, wide distribution reach, and proper positioning in the obese care pathway
