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And it appears endogenous GLP-1 does just that, it helps locally and temporarily to help suppress T-cell inflammation, the problem is that the half-life of endogenous GLP-1 is just a few minutes, so any systemic effects are somewhat muted
This analytical review critically examines the evidence surrounding GLP-1 agonists efficacy, safety, and real-world implications for obesity treatment in individuals without diabetes

Lam CS, Ramasundarahettige C, Branch KR, Sattar N, Rosenstock J, Pratley R, et al

Dopamine regulation and brain mechanisms One of the most significant findings across studies is the influence of GLP-1 receptor agonists on dopamine regulation
