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It avoids first-pass liver metabolism, which means lower risk of blood clots and a better lipid profile compared to oral estrogen
However, only a small number of patients were included in the study, and median levels were not elevated even before the commencement of GLP-1 RAs treatment (102)
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Sikiric assured me that the trial had been absolutely successful and that the data would be available very soon, but he declined to let me see it
