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In relation to this fact, suicide affects 2326% of BD patients, which represents about 3.414% of all suicide deaths [16], and sex-specific prevalence in this sense has also been observed, being relative suicide attempts higher in bipolar women, although less violent than men [11]

If you look across the randomized trials, the adverse event rates to me are fairly alarming

Upregulation of the downstream effectors of the insulin signalling pathway suggests that semaglutide treatment increases insulin sensitivity, a known effect of GLP-1R agonists that has not yet been shown on a cellular level in cardiomyocytes

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