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This is important because while a large number of immune cells in the gut are activated by GLP-1 very few immune cells containing GLP-1 receptors are present in other organs

Efficacy of probiotics in irritable bowel syndrome: systematic review and meta-analysis
51 Activated T cells in the TME are crucial for tumor cell elimination, but resistance can develop through upregulation of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), lymphocyte activation gene 3 (LAG-3), T cell immunoreceptor with Ig and ITIM domains (TIGIT), and T cell immunoglobulin and mucin-domain containing-3 (TIM-3) on T cells

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