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More specifically speaking, GLP-1 receptor activation facilitates the presynaptic release of GABA into RGCs via the Gs/cAMP/PKA/Phospholipase C (PLC)/IP3/Ca2+/CaM signaling pathway, ultimately increasing the GABAergic miniature inhibitory postsynaptic currents (m-IPSCs) frequency and contrast sensitivity ( The GABAergic modulation ability of GLP-1RAs is more thoroughly studied in brain tissues and cells

[3] In contrast, certain antidepressants may worsen glycaemic control

By enhancing these pathways, tirzepatide reduces hunger and promotes feelings of fullness, reducing calorie intake