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Ben: Yeah, it's interesting that this ended up being more of a manufacturing and scale advantage than an efficacy advantage
The first is that Eli Lilly was expecting greater non-diabetic weight loss with orforglipron based on phase 2 trials, and that apparently never happened for reasons that are still unclear
GLP-1 medications accounted for 5.4% of all American adult prescriptions in September 2024, up from 3.5% in 2023
Both involve adaptive thermogenesis, hormonal recalibration, and appetite feedback adjustments
