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Using a maintenance dose: For some people, reducing to a lower maintenance dose indefinitely or switching to a different medication can provide the extra support needed to maintain their progress long term

A major problem with their use is that once the medications are stopped, both the cravings and the weight come back unless sustainable changes in day-to-day food selections and lifestyle have been implemented

The second issue is plan design and eligibility

Under ad libitum feeding conditions, we found that heart, body, and heart/body weights and nonfasting tail blood glucose measurements were not affected by treatment assignment (Supplemental Figure 1