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Insurers said they had to withdraw coverage because the pricey medicines overwhelmed their budgets, forcing patients to either go off the drugs or pay for them out of pocket.

Various GLP-1RAs have been demonstrated to have significant benefits in in vitro and in vivo models of neurodegenerative diseases through modulating a variety of pathogenic mechanisms, including neuroinflammation, autophagy, mitochondrial dysfunction, and the abnormal phosphorylation of pathognomonic proteins

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However, the neuroanatomy of the GLP-1/GLP-1R system in the spinal cord is still poorly understood